Targeted inhibition of the metastatic process by biodegradable polymeric conjugates with MMP inhibitors and cytostatic drugs
Contractor: Institute of Macromolecular Chemistry of the CAS, v. v. i.; Institute of Microbiology of the CAS, v. v. i.
Principal investigator: Karel Ulbrich; Marek Kovář
Research years: 2017-2019
Metastasis is a multistep process which involves following key steps: 1) migration of tumor cells out of primary tumor, 2) their lymphatic or haematogenous spread, and 3) anchoring and growth. Matrix metalloproteinases (MMP) play a crucial role in the first step, while angiogenesis is essential for the capability to establish metastasis from a single cell. Biodegradable neovasculature-targeted polymeric conjugates of cytostatics (doxorubicin, docetaxel) and MMP inhibitors will be synthesized in order to simultaneously inhibit primary tumor growth and metastatic spread and their biological activity will be evaluated.